The one which actually happens depends on the balancing metal atom (organolithiums prefer to deprotonate at nitrogen due to the electronegativity difference, organomagnesiums deprotonate at C-3 for covalency).Thus by deprotonating indole with an alkylmagnesium bromide, an indole grignard reagent can be prepared.For the next five years, global TPA consumption is expected to increase at 4% per year.
You'd have to use an excess of HBr to brominate dimethyaminoethanol.
But once you have dimethylaminoethyl bromide, can you freebase it without a lot of quaternary amine polymer forming?
if the discussion is strictly scientific, it is probably permitted, but this one is definitely borderline.
Is it actually possible to form the Grignard with dimethylaminoethyl bromide?
During 2012–17, the DMT market contracted at an average rate of almost 8% per year.
However, as most of the shift from DMT to TPA has already taken place in the industry, consumption of DMT is expected to register only a marginal decline of 0.8% per year in 2017–22.And if I’d be interested in cookery I wouldn’t be asking questions on SM Melgar, indole itself can form a Grignard reagent of some sort: Since it is a pyrrole, the proton that lies on the nitrogen is actually fairly acidic, and so it can be deprotonated there to give a nitrogen-centered anion.However, the C-3 carbon is also fairly acidic due to ring resonance influenced by the benzene ring, so alternatively indole can be deprotonated there as well.The following pie chart shows world consumption of TPA/DMT: Polyester fibers ultimately account for more than 60% of TPA/DMT consumption.Another 33% goes into the manufacture of PET solid-state resin for bottles and other packaging applications.(this is all standard chemistry for the preparation of JWH-series cannabidinoids) Further, tertiary amines do not react with Grignard reagents, so I don't see why the Grignard reagent derived from dimethylaminoethyl bromide wouldn't exist (although there is potential for 1,2-rearrangements here) Although you are right, the OP here is still obviously a cook who is looking for a drug fix more than actual chemistry.[Edited on 9-1-2018 by Cryolite.]I do know little about chemistry, but I understand that there would be a lot of tertiary amine polymers forming, I was curious if the rate polymerization would still allow for this reaction.[Edited on 9-1-2018 by James Nilep] I have seen SM used for theoritacal discussions about illegal substances, that’s why I thought posting here would be appropriate, this is definitely not meant to be a discussion about “how do I make such and such illegal compound”, rather a theoretical question about an alternate synthesis pathway.I think the jury is still out on whether this thread violates the SM guidelines...The manufacture of polyester film, PBT, and other minor products such as cyclohexanedimethanol (CHDM), terephthaloyl chloride, and copolyester-ether elastomers accounts for the remainder of TPA/DMT consumption.Increasing demand for polyester fibers will drive future consumption of TPA/DMT.