The crude death rates (CDR), standardised death rates (SDR), standard expected years of life lost per...
more The aim of the study was to assess trends in mortality and years of life lost due to prostate cancer (PCa) in Poland in 2000-2015. The values of mortality rates in 2000 (per 100,000) were: CDR = 16.97, SDR = 16.17, SEYLL p = 332.1.
The aim of this study was to confine the expression of apoptin in the prostate tumor cells by inducing its gene expression under the control of a chimeric enhancer composing of prostate-specific membrane antigen (PSMA) and prostate-specific antigen (PSA) regulatory elements (PSES).
Furthermore, we investigated the effects of apoptin expression on LNCa P prostate carcinoma cell survival and apoptosis using MTT assay and annexin V/7-AAD flow cytometry assay.
UNBS3157, a naphthalimide that belongs to the same class as amonafide, was designed to avoid the specific activating metabolism that induces amonafide's hematotoxicity.
The current study shows that UNBS3157 rapidly and irreversibly hydrolyzes to UNBS5162 without generating amonafide.The crude death rates (CDR), standardised death rates (SDR), standard expected years of life lost per living person (SEYLL p) and per death (SEYLL d) values were calculated. In 2015, the values of all rates increased: CDR = 26.22, SDR = 16.69, SEYLL p = 429.5.However, the SEYLL d value decreased from 15.62 to one man who died due to PCa in 2000 to 13.78 in 2015.The aim of this study was to confine the expression of apoptin in the prostate tumor...more OBJECTIVES: Apoptotic effect of apoptin has been demonstrated in numerous studies.Our secondary aim was to verify if postoperative radiotherapy increases the risk of presenting...more Objective To know the incidence of vesicourethral anastomotic stricture in patients with prostate cancer treated with radical prostatectomy.Affymetrix genome-wide microarray analysis and enzyme-linked immunosorbent assay revealed that in vitro exposure of PC-3 cells to UNBS5162 (1 micro M for 5 successive days) dramatically decreased t...Objective To know the incidence of vesicourethral anastomotic stricture in patients with prostate cancer treated with radical prostatectomy.In vivo UNBS5162 after repeat administration significantly increased survival in orthotopic human prostate cancer models.Results obtained by the National Cancer Institute (NCI) using UNBS3157 and UNBS5162 against the NCI 60 cell line panel did not show a correlation with any other compound present in the NCI database, including amonafide, thereby suggesting a unique mechanism of action for these two novel naphthalimides.