There was moderate but short-lived response to electroconvulsive therapy, so she was considered for the ketamine infusion trial.
The ketamine was commenced at 15 mg/h (0.15 mg/kg/h) and titrated to 27.5 mg/h (0.27 mg/kg/h).
Based on this result, it was thought that a low-dose (subanesthetic) infusion of ketamine was worth a trial in patients who were suffering from treatment-resistant depression without other physical or psychiatric illness.
Approval for this trial was obtained from the hospital research and ethics committee.
Before and following each treatment with ketamine, at patient clinic visits, the Beck Depression Inventory (BDI) and the Hamilton Depression Rating Score (HAMD-17) were obtained.
The first two patients are described in detail: Patient A is a 39-year-old, 101 kg woman with an 18-month history of depression.
This recovery was not formally documented, as the primary concern was the treatment of the patient's pain.
Needless to say, it was not possible to quantify to what degree depression recovery was secondary to the patient's recovery from CRPS.
People who suffered a financial, housing-related, or job-related hardship as a result of the Great Recession were more likely to show increases in symptoms of depression, anxiety, and problematic drug use several years after the official end of the recession.
More A sample of research exploring memory and stress-induced cannabis craving, predicting suicidal thoughts and nonfatal attempts, the influence of stress on depression and substance use among same-sex couples, and heterogeneity of the anxiety-related attention bias.