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GCSE biology was the easiest thing ever so it's certainly a step up from that Another opinion: Having completed Units 1 - 6 at AS and sitting the exam soon.
In comparison to GCSE , it requires a lot more understanding and in depth knowledge of the subject matter.
Biology is my only science but from what I can gather from friends , everyone is finding it the most difficult.
In AQA there isn't coursework as such but you have an ISA similar to the one at GCSE but is more heavily assessed. If you're doing Edexcel there will be no practicals.
(ISA - Investigative Skills Assessment) About 20% of the exam is practical. There used to be an alternate to practical paper but they have changed the syllabus this year so dont know what they're doing now.
The exam style itself is quite hard in practice papers , as opposed to the "spraying" out of knowledge as GCSE you need to focus on the question and be very specific in your answers.
Another opinion: I find its easier and more interesting than chemistry.
Comment: From my experience, make sure you brief yourself on the whole of your A-Level course before your exams because you can be tested on things from your AS too on your second year.
Some of the questions you have to use some general knowledge for too.
If you enjoy reading biology topics especially human biology, it becomes easier to learn.
There are no 'hard' concepts -not in AS anyway-....